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Some bariatric practices, primarily these carried out underneath public-funded providers, have adopted attaining a goal preoperative weight loss (PrWL) earlier than providing surgical procedure. There are diverse opinions on the correlation between preoperative and postoperative weight loss (PoWL) for the completely different surgical choices. This examine investigated the impression of goal PrWL on PoWL for sufferers who underwent laparoscopic sleeve gastrectomy (LSG).

Supplies and strategies

A longitudinal retrospective cohort examine was carried out on sufferers who had documented preoperative weight earlier than LSG (n=155) from the authors’ establishment between February 2008 to October 2017. Sufferers had been grouped into two cohorts based mostly on assembly the 5% goal PrWL or not. The endpoint included % postoperative weight loss (% PoWL) at one 12 months and two to a few years.


A complete of 155 people had been recognized and analysed. Of those sufferers, 78.7% of them (n=122) achieved the 5% goal PrWL (goal group) whereas 21.3% (n= 33) didn’t (non-target group). At one 12 months, there was no statistical vital distinction within the imply % PoWL between the non-target and goal teams (22.3 ± 8.1% versus 19.4 ± 11.8% p worth= 0.08). An identical statement was made at two-three years, the place the imply % PoWL within the non-target group was 14.7 ± 10.7% versus 16.3 ± 14.4% within the goal group (p worth= 0.07). Our additional evaluation highlighted a statistically vital weak inversely proportional correlation between % PrWL and % PoWL at one 12 months and two to a few years.


Assembly goal PrWL doesn’t considerably impression on PoWL after LSG. Subsequently, it mustn’t function exclusion standards for eligible sufferers who’re in want of surgical procedure.


The stark epidemic proportion of weight problems is a actuality in at present’s world [1]. The World Well being Group (WHO) in 2014 revealed estimates that present a staggering 39% of adults to be chubby and 13% overweight [2]. Weight problems is related to comorbidities akin to metabolic illness (akin to kind 2 diabetes), cardiovascular and joint illness, sure varieties of most cancers, discount in self-reported high quality of life, and elevated mortality in the long term [3]. It poses an enormous well being burden on the person and has a big societal pressure when it comes to prices related to human sources, administration, and long-term affected person administration [4].

Surgical intervention has been proven to lead to larger enchancment when it comes to weight loss and obesity-associated comorbidities when put next with non-surgical interventions, whatever the process [5]. This epidemic proportion of weight problems has witnessed an attendant enhance in laparoscopic bariatric surgical procedure worldwide with estimates of about 468,609 procedures carried out as of 2013. Probably the most vital rise was that of laparoscopic sleeve gastrectomy (LSG) from Zero to 37% of the world complete from 2003 to 2013 [6].

The factors set out by the Nationwide Institutes of Well being (NIH) Consensus Improvement Convention panel for sufferers requiring gastric restriction or bypass procedures embody well-informed and motivated sufferers with acceptable operative dangers, physique mass index (BMI) exceeding 40 or between 35 and 40 with comorbidities (akin to extreme sleep apnoea, diabetes mellitus) and obesity-induced bodily issues. It doesn’t stipulate necessary goal preoperative weight loss (PrWL) [7].

Goal PrWL is commonly inspired amongst bariatric practitioners primarily public service funded providers, earlier than present process bariatric surgical procedure to enhance affected person compliance and outcomes [8-10]. Nonetheless, the impression of PrWL on a postoperative consequence akin to postoperative weight loss (PoWL) has remained controversial [11]. Some have challenged the requirement and efficacy of a preoperative goal weight loss earlier than present process bariatric process [12].

Subsequently, there may be nonetheless a must additional examine the importance of PrWL on PoWL, particularly in sufferers who underwent LSG.

Supplies & Strategies

This examine utilised de-identified knowledge from our bariatric database of sufferers on the authors’ establishment.

Cohort choice

We recognized all sufferers who underwent any bariatric operation (gastric band, Roux-en-Y gastric bypass, sleeve gastrectomy, or revisional surgical procedure) (n=339) from February 2008 to October 2017. A complete of 166 LSG had been carried out (included 11 revisions from gastric bands to LSG); nonetheless, observe up knowledge for 155 sufferers had been obtained and people with out documented postoperative weight after one 12 months excluded from the evaluation. Sufferers had been labeled as “goal” and “non-target” classes based mostly on assembly the 5% goal PrWL or not, and the 2 teams had been in contrast.


We centered on two variables. P.c PrWL (% PrWL) was decided by subtracting the burden at surgical procedure from the recorded weight at referral to the bariatric service (preliminary weight) divided by preliminary weight multiplied by 100. P.c PoWL (% PoWL) was outlined because the distinction of the post-surgery weight at one, or two-three years from weight at surgical procedure over the preliminary weight and expressed as a share.

Consequence measure

Our major consequence was % PoWL at one-year and two-three years follow-up. At our establishment, we observe up postoperative weights three months to 24 months postoperatively.

The Pearson correlation coefficient (r) was used to measure the connection between each variables. F-test was used to find out the general statistical significance of this relationship. All knowledge evaluation was carried out with Microsoft Excel 2013.


Knowledge from 155 sufferers was analysed. The median age was 50 years and there have been extra feminine than male sufferers. The common BMI at referral to the bariatric providers (begin BMI) was 48.5 Kgm-2. The common BMI at surgical procedure was 43.Eight Kgm-2 reflecting a median internet weight loss preoperatively from a median of 135.1 Kg to 119.7 Kg at surgical procedure. As seen in Determine 1, of the 155 sufferers, 78.7% of sufferers (n=122) achieved the 5% PrWL (goal) whereas 21.3% (n=33) didn’t (non-target). The youngest topic was 26 years and the oldest 62 years on the time of surgical procedure. 

At one 12 months, sufferers who didn’t meet 5% goal PrWL had a median % PoWL of 22.3 ±8.1% versus 19.4 ±11.8% for individuals who met 5% goal PrWL (p worth = 0.08) (Determine 2A).

At two to a few years, the common % PoWL for sufferers who didn’t meet the 5% goal PrWL was 14.7 ±10.7% (Determine 2B). This was barely decrease than the common % PoWL (16.3 ±14.4%) recorded within the cohort of topics who met the 5% PrWL goal (p worth =0.07).

Within the goal group, the correlation between PrWL and PoWL at one and two to a few years are detailed in Figures 34.

Within the non-target group of sufferers, the same relationship between each parameters was noticed (Figures 56).

Analysing mixed knowledge from all sufferers who underwent an LSG is depicted in Figures 78.


Bariatric (weight loss) surgical procedure as at at present is secure, efficient in producing vital sustainable weight loss, and results in the enchancment or decision of co-morbidities related to weight problems [13-14]. LSG as a bariatric possibility has quickly gained reputation and is taken into account the second most carried out bariatric process on the earth [15]. Regardless of the elevated acceptance of weight loss surgical procedure, lower than 1% of eligible candidates find yourself receiving surgical procedure in some climes [16]. In endeavor bariatric providers, some establishments have adopted a coverage of goal PrWL citing benefits akin to lowered peri-operative morbidity, decreased working time with much less blood loss, and doable motivation for additional weight loss [17].

On the authors’ establishment, the vast majority of the sufferers participated within the hospital’s preoperative program and are anticipated to realize a goal weight loss of 5% earlier than present process surgical procedure. Nonetheless, some who didn’t meet the goal weight loss however fairly fulfilled the NIH Consensus Improvement Convention and the Scottish Nationwide Planning Discussion board (NPF) pointers after bariatric multidisciplinary group (MDT) evaluate, had been supplied surgical procedure. We sought to find out whether or not goal PrWL impacted considerably on PoWL. Our examine noticed no sturdy correlation between PrWL and PoWL amongst the sufferers that had LSG at one and two-three years postoperative years.

In a meta-analysis accomplished in 2011 involving 17 trials and 10 research by Cassie et al. and a most up-to-date one in 2014 by Gerber et al. (included 23 publications and two evaluate articles), the authors had been inconclusive in regards to the impact of PrWL because of the heterogeneity within the varied examine designs [3,9].

In a single-center evaluate of 192 sufferers who underwent LSG throughout a nine-month examine interval, Parmar et al. reported no correlation between those that misplaced ‘excessive’ or ‘low’ preoperative weight (based mostly on comparability to the median % PrWL of 5.1%) and postoperative weight at one 12 months [18].

One other examine by Sherman et al. of their evaluate of 141 sufferers additionally recognized that PrWL shouldn’t be a dependable predictor of PoWL [11]. Watanabe A et al. of their work famous that the extent of PrWL didn’t contribute to raised weight loss throughout the total interval [15]. Our findings additional align with the above research that focus on PrWL doesn’t considerably impression on PoWL after LSG.

We recognise the limitation of this examine given its single institutional non-randomised evaluate nature, which can increase the potential of choice bias and should not solely undertaking the broader bariatric inhabitants.


Our examine noticed that attaining goal PrWL doesn’t considerably impression PoWL as reported in earlier research. Eligible bariatric candidates shouldn’t be denied surgical procedure based mostly on course PrWL. We suggest additional potential trials to delineate the impression of PrWL on LSG outcomes.